Hormone receptors in hepatoblastoma: A demonstration of both estrogen and progesterone receptors

SummaryThe pathogenesis of premenstrual tension syndrome is not fully understood. It has been hypothesized that the interaction between sex hormones and target organs is the key event in its pathogenesis. Aim: The purpose of the study was to examine the differences in the prevalence of smooth muscle cells with sex hormones receptors in varicose veins of women with and without premenstrual tension syndrome (PS). Patients, methods: Samples of great saphenous vein were obtained from 50 women during varicose vein surgery. They were divided into group I (20 women with clinically diagnosed PS) and group II (30 women without PS). Estrogen and progesterone receptors were detected with an immunohistochemical method. Superficial densities of smooth muscle cells positive to estrogen and progesterone receptors were analyzed with densitometric program IM-AN and automatic image analyzer Magicall. The results were compared with t-Student test. Results: There were no differences in superficial density of smooth muscle cells positive to estrogen receptors between the groups. In contradiction to this, superficial density of smooth muscle cells positive to progesterone receptors was higher in group with PS than in patients without, 343 (±171) and 240 (±123), respectively. The difference was statistically significant (p < 0.05). Conclusion: The amount of cells with sex hormone receptors, not the level of hormones, could play a role in PS pathology. Our results show that progesterone is more important than estrogen in effector organs.

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Study of ER PR receptors in breast carcinoma: a study of 30 cases

International Surgery Journal ◽

10.18203/2349-2902.isj20184654 ◽

2018 ◽

Vol 5 (11) ◽

pp. 3738

Author(s):

Himanshu R. Patel ◽

Ankur Shrimal ◽

Harsh P. Trivedi

Keyword(s):

Breast Cancer ◽

Retrospective Study ◽

Breast Carcinoma ◽

Hormone Receptors ◽

Tertiary Care ◽

Progesterone Receptors ◽

Care Hospital ◽

Breast Cancer Patients ◽

Estrogen And Progesterone Receptors ◽

Medical College

Background: Estrogen and Progesterone receptors are found in breast cancer cells that depend on estrogen and related hormones to grow. These are steroidal nuclear type of receptors. The most common method currently used to test a tumor for estrogen and progesterone receptors is immunohistochemistry or IHC. Patients with positive hormone receptor cancer have better survival. They are candidates of anti-hormonal therapy.Methods: This is a retrospective study was carried out in the Department of Surgery of a tertiary care hospital, affiliated to Government Medical College. This is a retrospective study in which 30 randomly selected case records of breast cancer patients, who presented in the period between 2011 to 2016, and who had undergone surgery, were taken and studied in terms of history, examination, investigations, treatment given, histopathology report and development of recurrence, metastasis and survival.Results: In this study out of 30 patients, 25 patients received adjuvant chemotherapy. 2 patients developed recurrence at local site.1 patient was ER/PR both negative and 1 patient was ER +/PR-. 3 patients developed metastasis. Among these, 2 patients were ER/PR both negative and 1 patient was having ER/PR both positive.Conclusions: Hormone receptors play a significant role in breast carcinoma. Breast cancer is more common in postmenopausal group as compared to premenopausal group. Mean age at diagnosis of breast cancer in western countries is 61 years and in India it is 50 years.

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The prognostic significance of estrogen and progesterone receptors in grade I and II endometrioid endometrial adenocarcinoma: hormone receptors in risk stratification

Journal of Gynecologic Oncology ◽

10.3802/jgo.2019.30.e13 ◽

2019 ◽

Vol 30 (1) ◽

Cited By ~ 11

Author(s):

Jun Guan ◽

Liying Xie ◽

Xuezhen Luo ◽

Bingyi Yang ◽

Hongwei Zhang ◽

...

Keyword(s):

Risk Stratification ◽

Hormone Receptors ◽

Endometrial Adenocarcinoma ◽

Prognostic Significance ◽

Progesterone Receptors ◽

Estrogen And Progesterone Receptors

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Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x1998000200005 ◽

1998 ◽

Vol 56 (2) ◽

pp. 193-199 ◽

Cited By ~ 10

Author(s):

ARLETE HILBIG ◽

LÍGIA MARIA BARBOSA-COUTINHO

Keyword(s):

Estrogen Receptors ◽

Mitotic Activity ◽

Hormone Receptors ◽

Immunohistochemical Study ◽

Progesterone Receptors ◽

Estrogen And Progesterone Receptors ◽

Brain Invasion ◽

Immunohistochemical Technique ◽

Histological Features ◽

Selection Of

The authors assessed 116 cases of meningiomas classified as typical, atypical and anaplastic and they used an immunohistochemical technique for estrogen and progesterone receptors attempting to determine if there is any difference between typical and non-typical tumors in relation to hormone receptors. The immunohistochemical technique to estrogen receptors was negative in all meningiomas studied. Progesterone receptors were detected in 58.3% of typical, and in 48.2% of non-typical meningiomas. This difference was not statistically significant. However, individually considering the criteria used for selection of non-typical tumours, those that concurrently displayed brain invasion and increased mitotic activity or necrosis, as well as the summation of those three features, were predominantly negative for progesterone receptors (respectively p=0.038; p=0.001; and p=0.044). The authors conclude that estrogen receptors were not present in meningiomas; that progesterone receptors in isolation are not enough to predict a higher tumoral malignancy but can be useful associated with other histological features.

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